When you start the driver for the first the time, the driver creates multiple instances of Windows Message Queues to store events for the respective domains. These queues are created using the credentials with which the Multi-Domain Active Directory driver is running.
In application mode, usually this is the credentials with which the user is logged in. You must ensure that all the subsequent driver startup must happen using this credentials or with other credentials having similar access rights to the Windows Message Queues.
In service mode, usually this is the system account of the Windows server. You must ensure that all the subsequent driver startup must happen using this credentials or with other credentials having similar access rights to the Windows Message Queues.
Switching between the application and service modes can result in state that will render the messaging queues to be inaccessible by the driver. In this scenario, you can start the driver using the Run As option with the credentials that has the access permissions to the queues.